Plasma Membrane Receptors
نویسندگان
چکیده
منابع مشابه
Plasma membrane receptors.
Receptors are macromolecules in or on cells that mediate physiological responses upon binding specific li-gands. Over the past few years, important advances have been made in the understanding of the biology of receptors, both at a basic and at a clinical level. Receptors bind their ligands with remarkable selectiv-ity and with high affinity, permitting a given physiological response to be elic...
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IP3Rs (inositol 1,4,5-trisphosphate receptors) are expressed in the membranes of non-mitochondrial organelles in most animal cells, but their presence and role within the plasma membrane are unclear. Whole-cell patch-clamp recording from DT40 cells expressing native or mutated IP3Rs has established that each cell expresses just two or three functional IP3Rs in its plasma membrane. Only approx. ...
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Although rapid signaling by estrogen at the plasma membrane is established, it is controversial as to the nature of the receptor protein. Estrogen may bind membrane proteins comparable to classical nuclear estrogen receptors (ERs), but some studies identify nonclassical receptors, such as G protein-coupled receptor (GPR)30. We took several approaches to define membrane-localized estrogen-bindin...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1987
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12470070